Urea may regulate urea transporter protein abundance during osmotic diuresis
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چکیده
منابع مشابه
Urea may regulate urea transporter protein abundance during osmotic diuresis.
Rats with diabetes mellitus have an increase in UT-A1 urea transporter protein abundance and absolute urea excretion, but the relative amount (percentage) of urea in total urinary solute is actually decreased due to the marked glucosuria. Urea-specific signaling pathways have been identified in mIMCD3 cells and renal medulla, suggesting the possibility that changes in the percentage or concentr...
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MAUIDE, DAVID L., AND LAURENCE G. WESSON, JR. Renal wuter reabsorption during saline and urea osmotic diuresis in the dog. Am. J. Physiol. 205 (3) : 477-482. rg63.-Free water reabsorption (TWC) was measured in conscious dogs during a longterm, reasonably steady-state osmotic diuresis induced either by sodium salts or by urea. After 4 to 8 hr the original solute was partially replaced by urea or...
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Urea transporters have been cloned from kidney medulla (UT-A) and erythrocytes (UT-B). We determined whether UT-A proteins could be detected in heart and whether their abundance was altered by uremia or hypertension or in human heart failure. In normal rat heart, bands were detected at 56, 51, and 39 kDa. In uremic rats, the abundance of the 56-kDa protein increased 1.9-fold compared with pair-...
متن کاملUrea Clearance and Diuresis in Man.
The ratio of the rate of excretion of urea to the concentration of urea in the plasma, that is, the urea clearance, has been known for many years to increase with the flow of urine (1). The quantative relation between the urea clearance and urine flow has been represented by numerous equations, each adequate for restricted ranges of urine flow. The most common of these equations, in this countr...
متن کاملOsmotic diuresis due to urea as the cause of hypernatraemia in critically ill patients.
BACKGROUND Hypernatraemia is common in critically ill patients and has been shown to be an independent predictor of mortality. Osmotic urea diuresis can cause hypernatraemia due to significant water losses but is often not diagnosed. Free water clearance (FWC) and electrolyte free water clearance (EFWC) were proposed to quantify renal water handling. We aimed to (i) identify patients with hyper...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Renal Physiology
سال: 2005
ISSN: 1931-857X,1522-1466
DOI: 10.1152/ajprenal.00200.2004